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10.1128/jb.00722-08 J

Metformin enhancement of therapeutic effects of 5-fluorouracil and oxaliplatin in colon cancer cells and nude mice

Like glucose, glutamine can be degraded to lactate and produce the nicotinamide adenine dinucleotide phosphate (NADPH) as a by-product of this flux via malic enzyme, contributing to fatty acid synthesis by facilitating the cells ability to use glucose-derived carbon [6,8,23,24]

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