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Many patients notice improvements in pain, inflammation, or recovery within 1-2 weeks, though timing varies based on the condition being addressed, severity of injury, route of administration, and individual healing capacity

Noteworthy, a limitation of the use of dynamic PDU is the contraindication of PGE1 administration in patients with recent CV or cerebrovascular events and with unstable hemodynamic conditions, and its careful administration in patients with risk of arterial hypotension, such as those in treatment with vasodilatory medications, particularly medications increasing NO production [42]

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