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Formation of presynaptic terminals at predefined sites along axons

San, H

In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice ( In summary, 25-OHC, NRF2, SPY1, and MPO regulate neuronal ferroptosis and lipid peroxidation, thereby participating in the pathological development of ALS

Both were removed because their nominations were withdrawn by nominators, and both are slated for PCAC consultation before the end of February 2027