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IGF-1 influences expression of genes that regulate protein degradation, peptide processing and presentation Defects in antigen presentation have been described in PCa cell cultures 24 , involving multiple components of the APM

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Subsequently, clinical studies with pembrolizumab, another anti-PD-1 monoclonal antibody, in mCRPC patients also proved ineffective, indicating that monotherapy with PD-1 inhibitors in this patient population did not yield significant objective responses (Scheid et al., 2016)