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Upon cessation, you might notice: Weight gain due to increased appetite and less satiety Increase in blood glucose levels, especially in people with diabetes Potential ongoing benefits to heart health despite weight regain Reversal of Ozempic face, a term describing facial changes from rapid weight loss Side Effects After Stopping Common side effects like nausea and diarrhea should decrease after discontinuing Ozempic, although the drugs long half-life means it may take about 5 weeks to clear from your system