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[DOI] [PubMed] [Google Scholar] Seilicovich A, Lasaga M, Befumo M, Duvilanski BH, del Carmen Diaz M, Rettori V, McCann SM (1995) Nitric oxide inhibits the release of norepinephrine and dopamine from the medial basal hypothalamus of the rat

Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]

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