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Burnett felt that making claims about the effectiveness of filters furthered concerns of smokings long-term effects. The initial Marlboro men were rugged characters such as sea captains, weightlifters, war correspondents and construction workers

Our findings expand new insights into the molecular mechanisms by which AZI restores CS-induced airway epithelial barrier dysfunction during COPD pathogenesis, providing experimental evidence for optimizing treatment strategies of COPD and target-based discovery and development of novel macrolides