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Interestingly, it was shown that transgenic lines in which HMA4 was silenced accumulated 4- to 6- fold more phosphorus (P), iron, manganese, and copper compared with control plants

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In damaging the airways and the lungs, smoking causes coughs, colds, wheezing and asthma as well as more severe issues like pneumonia, emphysema and lung cancer

The accumulation of norpropoxyphene seen with repeated doses may be largely responsible for resultant toxicity