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And a statistically significant increase in the incidence of lung cancer has been reported in several studies of chronically exposed workers. The EPA classifies acrylonitrile as a probable human carcinogen. Get CNN Health's weekly newsletter Sign up here to get The Results Are In with Dr

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However, despite its protective role, the constant activation of the Nfr2 pathway in response to e-cigarette use, particularly the flavouring agents found in e-cigarettes, can exhaust this protective pathway, leading to eventual cellular death in the epithelium (Ma et al

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