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Nicotine, an addictive chemical, can affect fetal brain development and can alter growth and function of the nervous system
(b) methodological differences such as prospective or retrospective study design, definition and classification of smoking habits (active smoker, never smokers, ex-smokers), quantification of exposure (pack years, duration of cigarette smoking) classification of CKD (proteinuria, serum creatinine levels, eGFR), duration of follow-up after cessation of smoking, presence of comorbidities, life style, health care system, and medications
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