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Regardless, the results align with independent measures of total cigarette consumption (Fig 3), estimates of cigarette butt densities in the literature (mean = 0.0012.7 butts/m 2 , max = 48.8 butts/m 2 ) [39, 45, 59], and the BRFSS smoking prevalence measure used in the model tracks trends in overall consumption over time (Fig 3), providing strong evidence that the model accurately reflects cigarette use in the U.S

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Data analyses were facilitated by grants from the National Eye Institute (R01 EY027004), the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK116738), and the National Cancer Institute (R01 CA241623)

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