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In February 2008, the FDA issued a statement which suggested that their evaluation indicates it is increasingly likely that there may be an association between Chantix and serious neuropsychiatric symptoms. In July 2009, the FDA required Pfizer to add a prominently displayed boxed warning about the risk of behavior changes, depression, hostility and suicidal thoughts, which is the strongest warning that can be placed on a prescription medication

doi: 10.1021/tx060208j

Early studies in immune cell metabolism identified aerobic glycolysis in neutrophils