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10.1038/s41418-024-01280-y 169 YangY.ZhongZ.XiaoY.ChenH
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Although these particular flavors are Generally Regarded As Safe by the Flavor Extract Manufacturers Association (FEMA) for ingestion, FEMA has not evaluated them for inhalation toxicity. They conclude: It is important for the FDA to identify and quantify flavor chemicals before authorizing Premarket Tobacco Applications (PMTA) for two reasons
Cigarette smoke negatively impacts air quality because tobacco smoke produces fine particulate matter, which is the most dangerous element of air pollution (for health)
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