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2000 titled Initial symptoms of nicotine dependence in adolescents. However, this time frame varies significantly based on several factors, including the frequency of use, the method of consumption (such as smoking or using smokeless tobacco), and genetic predisposition

The study used Ecological Momentary Assessment (EMA) methods to assess smokers daily stress experiences and smoking as they went about their day-to-day lives

However, further research is needed to determine the most effective treatment of nicotine dependence in adolescents, especially when it is associated with e-cigarette use

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