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After reviewing the companys PMTAs, the FDA determined that the applications lacked sufficient evidence to demonstrate that permitting the marketing of the products would be appropriate for the protection of the public health, which is the applicable standard legally required by the 2009 Family Smoking Prevention and Tobacco Control Act

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Given the ongoing debates about the health implications of electronic cigarette use, this systematic review aims to thoroughly investigate the direct effects of electronic cigarette use on human health, considering the characteristics of the populations studied and the duration of exposure