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One of the best ways to prevent cancer is to never start smoking and quit as soon as possible. Cigars sold in the United States come in three varieties: large cigars, cigarillos and little cigars

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These effects were markedly attenuated in KPC mice given metformin, which prevented nicotine-induced pancreatic carcinogenesis and tumor growth by up-regulating GATA6 and promoting differentiation toward an acinar cell program (50)