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Sample size calculations are based on a secondary aim, total plasma cotinine concentration (measured as nanograms per milliliter)

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Typical Symptoms of Active Pulmonary TB Persistent cough lasting more than 3 weeks Coughing up blood or sputum (mucus from deep inside the lungs) Chest pain or discomfort Fatigue and weakness Fever and chills Unexplained weight loss Night sweats Loss of appetite These symptoms occur because the bacteria are actively attacking lung tissue, causing inflammation and systemic illness

Ifeanyi Chukwunonso Okeke, the Director General of SON