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Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation

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Or it has spread to the lymph nodes or other parts of the body