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Supplementary Information 4: The doseresponse RR curves and their 95% UIs for all smokingoutcome pairs

If a patient is experiencing strong or frequent cravings, they may use a second piece within the hour Pharmacokinetics Both doses of Nicorette Gum demonstrated rapid onset in open-label, single-dose, crossover studies 1 Plasma concentration of nicotine over 12 hours after a dose of 2-mg Nicorette Gum vs

Additionally, most adults who used nicotine pouches were aged 21-24, but over a quarter of individuals who currently use this product are underage - ages 18-20