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Any tobacco use, including e-cigarettes, is a health threat, particularly to young people. Tobacco companies have fought efforts to cut e-cigarette flavors, stating they are not aimed at youth, but at adults, as an option to help transition from tobacco cigarettes

According to 22nd Century, government-funded research is trying to answer a number of questions about low-nicotine cigarettes, including how different nicotine levels in cigarettes affect smoking behavior, at what level nicotine is no longer addictive and whether a gradual or an immediate reduction in cigarettes' nicotine content to non-addictive levels is more favorable for smokers

Ontario's combined federal excise duty and provincial tobacco tax is among the highest in Canada

It has been linked to an increased risk of colon, pancreatic, esophageal, and stomach cancer, too