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For example, the efficacy of silibinin for the treatment of type 2 DM (T2DM) has been verified by research that demonstrated that silibinin could ameliorate the inhibition of PINK1-Parkin-mediated mitophagy in INS-1 cells treated with palmitic acid and high glucose, thereby attenuating ferroptosis to rescue cell loss [111]

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Given concerns over workload and time available to deliver the intervention, coupled with the demand to extend the intervention to all out-patient department (OPD) patients, the congruence of the intervention was a key concern