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INTRODUCTION The prevalence of tobacco use remains alarmingly high across the globe, with statistics indicating 942 million male and 175 million female smokers aged 15 years 1

Box 1: Evidence for snus as a smoking cessation aid In 2023, meta-analyses of randomised controlled trials found snus did not increase smoking cessation compared with control conditions (placebo or no product, risk ratio (RR) 1.33 [95% CI 0.71 to 2.47]) or nicotine replacement therapy (NRT) (RR 0.62 [95% CI 0.27 to 1.41])

Interestingly, Balbo et al investigated the carcinogenic effects of NNN enantiomers, (S)-NNN and (R)-NNN, in rats [33]

On its 50th anniversary, Casio stepped outside the conventional box with this new design