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Pointwise p-values The left-sided p-values (appropriate because the treatment effect is negative) show significance at the 5% level in 8 of 12 post-treatment years: Time | Treatment Effect Left-sided p-value 1989 | -7.4201 0.0500 1990 | -9.5789 0.1000 1991 | -13.2182 0.1500 1992 | -13.9061 0.1000 1993 | -17.6228 0.0500 1997 | -23.8174 0.0500 2000 | -25.5478 0.0500 The four years with weaker significance (19901992 and 1998, with p = 0.100.15) reflect periods when the treatment effect was smaller in magnitude
This is because smoking hardens the oral mucosa and kills all bacteria that cause ulcers
He talks about how she hates runny eggs, disdains money and thinks his jokes are corny (which he rhymes with convict movies make her horny)
and, of course, in the early twenty-tens, the frenzied period in which, after being fired from Two and a Half Men, Sheen overtly embraced his role as a proudly drugs-and-sex-obsessed rebel with tiger blood pulsing through his veins, touring the country with a retinue of adult actresses to proclaim his rejection of polite societys pieties, and braying the catchphrase Winning! at seemingly anyone and everyone he came across
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