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A study found a 1.66-fold increase in CYP1A2 activity in smokers of 1120 cigarettes per day, which is reversed after smoking cessation (Tantcheva-Por et al., 1999)

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Cytochrome P450, a family 1, subfamily A polypeptide 1 (CYP1A1) is another xenobiotic metabolizing enzyme that participates in the metabolism of PAHs