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Similar to menthol, synthetic cooling agents (including WS-3 and WS-23) also activate TRPM8 with increased efficacy (WS-3) and with comparable half-maximal concentrations (WS-3: 2-4M

Chuersuwan, N., Nimrat, S., Lekphet, S

Funding This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2020R1C1C1004999), the Korea Health Industry Development Institute (KHIDI)-AZ Diabetes Research Program, and a grant from the Korea Health Technology R&D Project through KHIDI funded by the Ministry of Health & Welfare, Republic of Korea (HI19C1194)

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