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Examination of the association between smoking and frequency of hangover must also consider consumption of alcohol in order to account for differences in both variables that might be attributable to confounds with amount of alcohol consumed, or sex differences in alcohol metabolism or in threshold for inducing hangover (Jackson, 2008)

The FDAs workforce skews toward older workers who have spent one or two decades at the agency, and the Government Accountability Office noted in 2022 that the FDA has historically faced challenges in recruiting and retaining staff due to better money in the private sector

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