Une cigarette peut parfois ne pas contenir de tabac du tout, ou renfermer d'autres produits vgtaux, y compris d'autres agents psychotropes tels que le cannabis ou des clous de girofle (kreteks)
Conversely, Staudt et al., in a trial with healthy non-smoking subjects exposed to both nicotine-containing and nicotine-free e-cigarettes, noted genetic changes in small airway epithelial cells, alveolar macrophages, and lower airway mononuclear phagocytes after short exposure to EC aerosols
Another potentially worrisome trend is the increase in initiation by young adults (1824) and a possible increase in occasional smoking that may be associated with it
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