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This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)

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With the passage of time, this unremitting exposure results in inflammation, compromised immunity, harm to tissue, and even cell mutationfactors that elevate the risk of cancer