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Cannabis (marijuana) Epidemiological studies indicate high rates of cannabis use disorders among individuals with schizophrenia, with lifetime prevalence of 13% to 64%.16 Evidence from longitudinal studies shows an increased risk of schizophrenia and psychotic symptoms following heavy cannabis use.17 Previous studies have proposed self-medication with cannabis to remedy symptoms of schizophrenia.18 In contrast to these studies, recent data show that cannabis misuse often occurs before the onset of psychosis and that psychotic and affective symptoms worsen after cannabis use.19 Two recent meta-analyses have addressed the relationship between cannabis use and neurocognition in schizophrenia