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Robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and toxicology Provides a sensitive cell-based assay of drug responsiveness to identify inhibitors relevant to neurodegenerative disease in an authentic cellular context Reliable and simple assay doesnt require non-physiological protein mutations or genetically engineered cell lines Validated under a wide range of conditions and with small molecule modulators demonstrating suitability for screening compounds of potential therapeutic value Fixed-cell assay is optimized for antibody co-localization studies Easily quantifies aggresome and related inclusion bodies by flow cytometry Useful for the study of neurodegenerative diseases, liver disease, toxicology studies and much more Aggresomes are inclusion bodies of aggregated, misfolded proteins that form when the ubiquitin-proteasome protein-degradation machinery is overwhelmed

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FDA Issues Proposed Rule on Front-of-Package Nutrition Labeling On January 14, 2025, the U.S