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They concluded that Nicotine acts as a gateway drug and exerts a priming effect on cocaine by means of HDAC inhibition . Evidence from a 2011 animal study appearing in the Journal of Science Translational Medicine showed that exposing mice to nicotine during their early developmental stages made them more responsive to cocaine later on
Fifty-six individuals with MetS participated in a double-blind trial
Attrition analyses found modest differences between those with and without follow-up data on key variables and no differences in baseline e-cigarette use, sug- gesting that the impact of attrition on association estimates was small
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