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Also, cigarette smoke decreased the relative mRNA and protein expression of glutamate transporter1 (GLT-1) and the cystine-glutamate transporter (xCT) in the PFC and the NAc, while ASA treatment normalized their expression

For example, US evidence suggests that flavoured ENDS sales restrictions were associated with reduced vaping but increased cigarette smoking among young adults, potentially offsetting some public health gains [106]

This is hugely important as the former smoker develops new responses to any habitual triggers to smoke over the first few weeks of being a happy non-smoker

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