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Interestingly, a case study showed that biological response to cigarette smoke can be compared across five different systems if datasets are normalized as a function of dose (g/cm 2 ) and nicotine concentration (mg) [47]

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Because Health Canada has not yet approved e-cigarettes as delivery vehicles for nicotine, they are illegal to sell in Canada.Reference Czoli, Reid and Rynard 2 Regardless, both nicotine and non-nicotine containing e-cigarette products are widely available for purchase in Canada