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Based on these studies, it appears that nicotine concentration of the e-liquid used is a major determinant of e-cigarette puffing topography (Cunningham et al., 2016

Similarly, aerosol inhalation can result in enhanced airway resistance [45] and increased sympathetic nervous system activity [46], factors contributing to elevated risk for the development of cardiopulmonary disorders [10, 47]

The sudden quiet can make small discomforts stand out, including mild withdrawal starting to creep in

This is a strategy the FDA should not endorse when considering benefit to the public health. We are still awaiting decisions on the most popular e-cigarettes The FDA has yet to announce decisions on the most popular Vuse products, as well as leading brands JUUL, blu, Logic, and NJOY which comprise over 75% of the retail market