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But biology matters too Beyond quantity, there are several factors that can change how strongly you feel the effects: Metabolism: Some people break down alcohol and its byproducts faster than others Genetics: Differences in enzymes (like those that process acetaldehyde) can affect how your body reacts Sleep quality: Poor or fragmented sleep can make symptoms feel worse the next day Food intake: Drinking on an empty stomach can increase how quickly alcohol is absorbed Other habits: Smoking, stress, and overall health can all play a role These variables help explain why the same drink can feel different depending on the situation

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Psychological impacts: Anxiety and depression Nicotine changes the brains chemistry, affecting mood and pleasure

Fattahi F, Hylkema MN, Melgert BN, Timens W, Postma DS, ten Hacken NH