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These may include: burnt toast burning rubber cigarette smoke a chemical or metallic smell a spoiled or rotting smell a stale or moldy smell People are often unable to identify the specific smell, or it may be a smell that they have never encountered before

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Acknowledgements The authors thank the participants and the medical staff from the MEDYK Medical Center in Rzeszw, Poland for the recruitment of study participants and collection of biological materials

Recognizing the factors that contribute to heavy smoking and adopting effective strategies for reducing or quitting smoking can lead to significant health benefits and an improved quality of life