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The team focused on 378 genetic variants that have previously been linked to whether people start smoking, as well as 126 genetic variants the team found were linked to a higher score for lifetime smoking a measure encompassing how heavily people smoked, for how long, and if they quit

Smoking-induced apoptosis of pulmonary vascular endothelial cells is critical in initiating and contributing to the pathogenesis of COPD, solidifying smoking as a primary risk factor for this disease 9

The net result

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