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Bacteria found in the tobacco easily enter the bloodstream through the mouth "A further danger is that several species of Bacillus, as well as some Stapphylococccus epidermidis and Staphylococcus hominis strains can reduce nitrates to nitrites, which can potentially lead to formation of carcinogenic, tobacco-specific N'-nitrosamines within the tobacco products." And as many users often have problems with gum disease and other oral health issues caused by the smokeless tobacco products, this allows bacteria to easily enter into the bloodstream