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Nicotine may slightly affect blood flow, but these products lack the oxidative stress and toxins from cigarettes that drive most smoking-related shedding

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[79] demonstrated that Plasma sE-cadherin levels were significantly lower in patients with COPD and symptomatic smokers than in healthy smokers and healthy non-smokers, and sE-cadherin levels were associated with the severity of airflow limitation in COPD and symptomatic smokers plasma