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Incorporating timing and dose-response effects, we hypothesized that: (i) smoking is associated with an increased likelihood of current and lifetime depression, (ii) a higher number of cigarettes per day is associated with more severe current depressive symptoms, (iii) an earlier age at initiation of smoking is associated with an earlier age at onset of depression, (iv) a longer time since smoking cessation is associated with a longer time since the last depressive episode, and (v) a longer time since smoking cessation is associated with reduced severity of current depressive symptoms (Fig

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The scientists are from the Association of Optometrists (AOP) in the United Kingdom