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ACKNOWLEDGEMENTS This work was supported by the Unit of Excellence on Clinical Outcomes Research and IntegratioN (UNICORN), School of Pharmaceutical Sciences, University of Phayao

A large body of evidence showed that direct skin exposure to cigarette smoke containing a large number of oxidants and radical species 40 leads to lipid peroxidation 41 associated with the skin barrier impairment demonstrated by the increased TEWL in various experimental models 5, 6 as well as in the cheek of smokers 4

And as a powerful neuroprotectant, caryophyllene can be useful against inflammatory pain by interacting with the CB1 and CB2 receptors in our brains