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Given that the current increase in smoking risk is in contrast to the improvement in other risk factors, the findings suggest that vaping may be undermining the progress of successive public health and anti-tobacco policies implemented over five decades

A report examining PMI data on Sprague Dawley rats exposed to IQOS smoke or CS for 90 days observed increased markers of acute hepatotoxicity, including liver weight and alanine aminotransferase, in the IQOS-exposed group 54

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131 Therefore, it is not surprising that in people exposed to CS, a significant decrease in salivary total antioxidant capacity (TAC) is observed