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A number of studies have shown that cigarette smoke can induce cell apoptosis in the esophagus and gastric mucosa (24), as well as in the inner layers of the small intestine and colon (25)

Where our specification of this model differs from the LaFaive, Fleenor and Nesbit (2008) specification is in this second stage

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Despite a questionable reliability in both studies because they were based on a diagnostic evaluation from a questionnaire, these were the only populational evaluations so far that have identified risk factors for the development of chronic rhinosinusitis