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Different studies have shown that cigarette smoke causes a reduction in cell viability and induction of apoptosis in respiratory hair cells20, opposite mitogenic effects or pro-apoptotic depending on the cigarette smoke concentration21 or even an impairment on epithelial regeneration upon injury.22 Animal studies have shown that chronic and intermittent exposure to cigarette smoke cause morphological alterations to the epithelium of the entire respiratory tract, from hyperplasia in lower concentrations, all the way to loss of cilia and metaplasia with keratinization in higher concentrations, and also submucosal thickening and inflammation with neutrofilic and mononuclear inflammatory cells infiltrate.23 Also, Hamm et al.24 showed that the cigarette-induced respiratory mucosa inflammatory reaction persists even after seven months of recovery

Regarding tobacco-smoking and alcohol cessation, one meta-analysis has shown that smoking cessation interventions during addiction treatments were associated with a 25% increased likelihood of long-term abstinence from alcohol and illicit drug use 29

It is an Americanism for the Mexican Spanish marihuana or mariguana, which is associated with the personal name Mara Juana