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Inhaling it into the lungs was the exception rather than the rule: even among those who smoked it, many preferred to swallow the vapour into the stomach

One of the primary mechanisms involves the cytochrome P450 enzyme system , a group of liver enzymes responsible for metabolizing many medications, including antidepressants

References (click to expand) Chemicals in Cigarettes and Tobacco: What's Burning

Specifically, studies have shown that e-cigarettes exacerbate airway inflammatory responses, elevate levels of type 2 inflammatory cytokines such as IL-4, IL-5, and IL-13, increase cellular oxidative stress, and impair lung function