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And it's hard to get animals to self-administer nicotine the way they will with cocaine. More significantly, there is increasing evidence that nicotinic receptor function may play a significant role and nicotine may be a therapeutic target in neurodegenerative disorders such as Alzheimers and dementia, as well as schizophrenia, Parkinson's disease, anxiety disorders, and attention deficit-hyperactivity disorder (ADHD)

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To address the possibility that this was due to a general defect of autophagy caused by tau, we assessed autophagic flux in cells expressing GFPLC3 and hTau or hP301L (Fig EV1)