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In addition, cigarette smoke harbors high levels of acrolein, a recognized toxic compound to the pulmonary cilia, as well as other agents (such as acetaldehyde, formaldehyde and nitrogen oxides) that could indirectly contribute to the mechanism of pulmonary carcinogenicity

While data are limited, the agency does not expect non-smokers to start using the reduced nicotine products, and those who do are unlikely to develop nicotine dependence, the agency stated

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