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The effect sizes were actually quite large and meaningful given the number of people who might be exposed to this marketing strategy. For the study, published in the American Journal of Preventive Medicine , Duan and colleagues analyzed data from a nationally representative sample of nearly 20,000 American adults that spanned a four-year period

38 With 39- and 40-Across, classic Shakespearean question phonetically suggested by 17-, 23-, 47- and 59-Across : TO BE 39 See 38-Across : OR NOT 40 See 38-Across : TO BE There has been centuries of debate about how one interprets Hamlets soliloquy that begins To be or not to be

Unlike medications that can be pulled from the market by the FDA for causing severe side effects, cigarettes cant be banned by the the agency