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We characterized the impact of nAChR agonists on brain function using the ALE framework (paralleling that described above) and separately identified brain regions showing either convergent activity increases or decreases using a cluster-level corrected threshold ( p corrected 4000 compounds present in tobacco smoke [67], and/or be mediated directly or indirectly by nicotine itself

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Additionally, the physical capacity and frailty status in the older adult, which affect this process, are also significant factors contributing to the increase in ASDRs and ASMRs (30).However, the phenomenon observed in our study, where ASDRs and ASMRs decrease among individuals aged over 90, may be related to the antagonistic effect between telomere attrition, stem cell exhaustion, and tumorigenesis