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Your liver transforms the nicotine consistently over a few hours, and your cotinine levels increase

Smoking Exacerbates Effects of Dietary Fat on Liver Animal experiments using first-hand (delivered via a smoking device designed to puff the smoke into the inhalation chamber housing the animals), second-hand smoke (side-stream whole smoke solution delivered via a puffer box), or nicotine and models of genetic or diet-induced obesity (DIO) provide perhaps the strongest evidence linking nicotine to hepatic steatosis and NAFLD

The research was supported in part by the National Heart, Lung and Blood Institute, part of the National Institutes of Health.

Additionally, chewed tobacco was employed as a disinfectant for cuts and bruises, as an emollient for venomous bites, and to treat internal infections and inflammations